Poster Presentation Society for Molecular Biology and Evolution Conference 2016

Mitochondrial Genomes Reveal the Complex Demographic History of Human Populations in Eastern Pamirs (#650)

Min-Sheng Peng 1 2 , Wei-Fang Xu 3 , Jiao-Jiao Song 1 4 , Xing Chen 1 , Xierzhatijiang Sulaiman 3 , Shi-Fang Wu 1 , Gui-Mei Li 1 , Najmidinov T Abdulloevich 5 , Manilovna E Afanasovna 5 , Khudoydodov B Ibrohimovich 5 , Xi Chen 6 7 , Halmurat Upur 3 , Ya-Ping Zhang 1 2 8
  1. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
  2. KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan, China
  3. Xinjiang Medical University, Ürümqi, Xinjiang, China
  4. Institute of Health Sciences, Anhui University, Hefei, Anhui, China
  5. E.N. Pavlovsky Institute of Zoology and Parasitology, Academy of Sciences of Republic of Tajikistan, Dushanbe, Tajikistan
  6. Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Ürümqi, Xinjiang, China
  7. Research Center for Ecology and Environment of Central Asia, Chinese Academy of Sciences, Ürümqi, Xinjiang, China
  8. Yunnan University, Kunming, Yunnan, China

Eastern Pamirs is among the world’s highest mountains in Central Asia. The population history for this region is still unclear. To address this issue, we analyzed mitochondrial DNA (mtDNA) sequence variations in Sarikoli (n=89), Wakhi (n=67), and Kyrgyz (n=69) populations from East Pamirs in Xinjiang, China. The surrounding lowland populations, including Tajiks (n=28) from Tajikistan, Kyrgyz (n=54) and Uyghur (n=27) people from western Xinjiang, China, were also investigated for comparisons. A total of 334 mitochondrial genomes were sequenced by using Ion Torrent PGM. The mtDNA haplogroup profiles for those populations were indicated. And some novel sub-haplogroups within haplogroups D4 and H were classified. In addition to East (e.g. A – D) and West (e.g. H – K) Eurasian mtDNA haplogroups, some South Asian specific lineages (e.g. M3 and M5) were detected in most populations. Within those haplogroups, the distribution of related sub-haplogroups showed differences among those populations, suggesting a complex admixture history in Eastern Pamirs. The Bayesian Skyline plots revealed different demographic history between highlanders and their surrounding lowlanders.